APC and colorectal carcinoma: It was reported that the depletion of α-ketoglutaric acid and glutamine could activate Wnt-signaling and promote cancer dedifferentiation in CRC with Apc mutation in mouse and human ex vivo organoids, whereas the supplementation of α-ketoglutaric acid antagonized tumorigenesis through epigenetic reprogramming (Tran et al., 2020).