IDH1 and central nervous system cancer: Multivariate Cox regression indicated that the GRMS remained a risk factor (hazard ratio (HR) > 1.00) with statistical significance (p < 0.05) after adjusted by available clinical and pathological features of gliomas, such as age, gender, histology, IDH mutation status, and chromosome 1p19q codeletion status, which suggested that the GRMS could be identified and validated as an independent risk factor for OS of glioma patients (Supplementary Figures S5A–F)).