CHSY1 and central nervous system cancer: With the higher number of connections with activated pathways, including epithelial–mesenchymal transition (EMT) and the phosphoinositide 3-kinase (PI3K)/AKT serine/threonine kinase 1 (AKT)/mechanistic target of the rapamycin kinase (mTOR) pathway, PYGL, MFNG, CHSY1, STT3A, HAS2, and B4GALT4 demonstrated a sophisticated association with tumor promotion in gliomas (Figures 2A, B).