CD274 and neoplasm: Moreover, except the Rembrandt set, as to the immune checkpoints, the estimated GRMS demonstrated a strong correlation with CD274 expression level in the CGGA set (cor = 0.39, p < 0.001), Gravendeel set (cor = 0.45, p < 0.001), TCGA set (cor = 0.54, p < 0.001), meta-cohort (cor = 0.41, p < 0.001), and Kamoun (cor = 0.35, p < 0.01), which indicated that patients in the high-GRMS group might respond to anti-tumor immunotherapy (Supplementary Figures S10A–E).