IL10 and central nervous system cancer: Remodeling of glioma-associated macrophages (GAMMs) promotes an increase in the production of immunosuppressive cytokines, such as interleukin-10 (IL-10) and transforming growth factor ß (TGF-β), relative to that in healthy donors (Coniglio and Segall, 2013), which supports the formation of a supportive microenvironment for an inefficient antitumor immune response (Garcia-Fabiani et al., 2020).