Glycosyltransferase alterations could change the nature of the TME and reverse adverse characteristics of TME cells, altering a “cold tumor” into a “hot tumor.” For example, the changed glycosyltransferase motifs on Mucin 1 (MUC1) could promote cancer immune surveillance by interacting with CD169, which enhances macrophage activation after binding to sialylated MUC1 and promotes tumor growth (Reily et al., 2019). The gene discussed is MUC1; the disease is cancer.