This, together with the impaired apoCaM/NaV1.5 IQ-domain interaction presented in this work, opens a possible mechanistic explanation for the clinical presentation observed for the CaM-G114R carriers, who died suddenly at a very young age while asleep, potentially triggered by a fever from the infections they each had at the time of death (Brohus et al., 2021). This evidence concerns the gene SCN5A and infection.