RYR2 and catecholaminergic polymorphic ventricular tachycardia: In 2021, we showed that the G114R variant impairs CaM’s ability to bind Ca2+-ions and to interact with and regulate CaV1.2 and RyR2, with an impact suggesting an arrhythmogenic potential consistent with CPVT, IVF, or mild LQTS (Brohus et al., 2021).