In 2021, we showed that the G114R variant impairs CaM’s ability to bind Ca2+-ions and to interact with and regulate CaV1.2 and RyR2, with an impact suggesting an arrhythmogenic potential consistent with CPVT, IVF, or mild LQTS (Brohus et al., 2021). Here, RYR2 is linked to familial long QT syndrome.