Tavares LC et al. (Tavares et al., 2018) and Amin A et al. (Amin et al., 2014) studies also showed that patients with higher TTR had lower rates of adverse events such as bleeding and thromboembolism, and that patients were more likely to have bleeding or embolic events when the TTR was ≤60%. Here, TTR is linked to Thromboembolism.