Finally, through functional enrichment analysis, we found that PDE4DIP had a critical impact on the immunotherapy of various cancers, i.e., PDE4DIP expression was mainly associated with immune-related pathways such as JAK-STAT signaling pathway, chemokine signaling pathway, and NOD-like receptor signaling pathway, and in LAML, PDE4DIP expression was also related to immune modulators such as immunoglobulin complexes and T-cell receptor complexes. The gene discussed is PDE4DIP; the disease is cancer.