PDE4DIP and inborn error of immunity: GSEA showed that PDE4DIP was most markedly enriched in immune-related pathways in LAML, including primary immunodeficiency, intestinal immune network for IgA production, viral protein interaction with cytokine and cytokine receptor, cell adhesion molecules, chemokine signaling pathway, B cell receptor signaling pathway, Th17 cell differentiation, T cell receptor signaling pathway, and JAK-STAT signaling pathway (Figure 8a).