Prognostic analysis based on OS, DSS, DFI, and PFI indicated that high expression of PDE4DIP had a potential prognostic effect on some cancers, with a poor prognosis in LAML, PCPG, THYM, UVM, and HNSC patients, and a good prognosis in PAAD and PCPG patients. Here, PDE4DIP is linked to pancreatic adenocarcinoma.