To assess the extent of CIN upon Mcl-1 deficiency, whole exome sequencing (WES) was performed on DNA isolated from 27 discrete hepatocellular neoplasms excised from the livers of a total of 15 Mcl-1Δhep mice, which were histologically classified as dysplastic nodules (DNs, n = 14) or as HCC (n = 13). Here, MCL1 is linked to hepatocellular carcinoma.