CASP3 and acute respiratory distress syndrome: The results showed that sesamin treatment at 3 or 6 hr post-APAP also could effectively attenuate the APAP-induced ALI, as indicated by reduced serum ALT and AST activities (Figures 8(a) and 8(b)) as well as hepatic caspase 3 and 8 activities (Figures 8(c) and 8(d)).