CD274 and neoplasm: Additionally, a recent study that combines NC410 with Bintrafusp-alfa, a PD-L1 mAb fused with TGF-βRII demonstrated an even better outcome than NC410 with PD-1 blockade, suggesting the combination of checkpoint blockade and TME-ECM remodeling synergize to remodel immune responses in favor of anti-tumor immunity (79).