In this case, knowledge of a relevant autoantigen for CD4 Treg, and a relevant antigen for regulatory CD8 T cells, such as a peptide of a dominant Vβ TCR expressed on autoreactive CD4 T cells or a peptide presented on non-classical MHC recognized by suppressor CD8 T cells, would again likely be needed to allow specific targeting and inhibition of the T cells that drive autoimmunity or other inflammatory diseases (169). The gene discussed is CD8A; the disease is Autoimmunity.