Another DMP separating “all” psoriasis patients from controls was DUSP22, encoding for a protein phosphatase responsible for activation of the c-Jun NH2-terminal kinase (JNK) signaling pathway that is dysregulated in psoriasis (102), SLE (103) and ankylosing spondylitis (104). The gene discussed is MAPK8; the disease is ankylosing spondylitis.