DMPs (N=20) (correlation cut-off 0.9) most predictive of psoriasis (PLS-DA component 1) included cg01877366 in Trafficking Protein Particle Complex Subunit 9 (TRAPPC9), cg1120622 in Reversionless 3-like (REV3L) and cg18925478 in Phosphatase and Actin Regulator 2 (PHACTR2) (Figure 1D; Supplementary Table 3), all of which have previously been reported in the context of psoriasis, PsA (31, 32) or other autoimmune diseases (18). The gene discussed is PHACTR2; the disease is autoimmune disease.