Notably, 69.2% (379 of 548) of differentially methylated genes between “all” psoriasis patients and control are involved in IFN signaling with equal distribution between type I IFN (19.7%), type II IFN (21.9%), or both (21.9%) (Figure 3A; Supplementary Tables 6, 7). Here, IFNA1 is linked to psoriasis.