Thus, the role of TNFR2 signal in orchestrating the inflammatory responses in autoimmune diseases or immune responses in cancers is complicated, and the mechanism may be involved in the activation of Tregs, MDSCs, CD8+ T cells and ADCC, or inversely, depletion of Tregs in tumor environment (summarized in Table 1). This evidence concerns the gene TNFRSF1B and cancer.