KEGG analysis revealed that DEGs were mainly enriched in cancer-associated pathways, including the PI3K-Akt signaling pathway, EGFR tyrosine kinase inhibitor resistance, PD-L1 expression and the PD-1 checkpoint pathway in cancer, and the chemokine signaling pathway (Figure 3B), implying that immunogenic cell death acts as a crucial factor in the progression of RCC. The gene discussed is AKT1; the disease is cancer.