Research has shown that Chromebox protein homolog 3 (CBX-3) is a positive modulator of glycolysis in pancreatic cancer cells, and that blocking the CBX3-FBP1 signaling axis inhibits aerobic glycolysis, which suggests that this approach may be useful in the treatment of pancreatic cancer (30). The gene discussed is FBP1; the disease is familial pancreatic carcinoma.