Since it has been demonstrated that IL-1 inhibits STAT3’s chromatin accessibility in a chondrosarcoma cell line (31), IL-21 may reverse this inhibition and induce the proliferation of IL-1-stimulated Vγ4+nγδT17 cells but not Vγ6+nγδT17 cells. The gene discussed is IL1B; the disease is chondrosarcoma.