IL6 and rheumatoid arthritis: IL-6 activating NF-κB via phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/AKT) signaling is thought to be the main pathway for inducing CEMIP expression in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs) (13).