The end result is that a large number of immunosuppressive cells, such as MDSCs, regulatory T (Treg) cells, and tumor-associated macrophages (TAMs), and a large number of anti-inflammatory factors, such as IL-10 and TGF-β, are accumulated in the tumor microenvironment to jointly promote tumor immune escape, growth, and metastasis (48). The gene discussed is TGFB1; the disease is neoplasm.