CEMIP activates downstream regulatory molecules by promoting the phosphorylation level of some signaling molecules and further regulates target genes that relate to tumor cell activities among multiple signaling pathways, including Notch, Wnt/β-catenin, epidermal growth factor receptor (EGFR), PI3K/Akt, signal transducer and activator of transcription 3 (STAT3) (60–68). The gene discussed is EGFR; the disease is neoplasm.