CEMIP and chondrosarcoma: Stimulation of chondrosarcoma cells with cytokines IL-1β, TNF-α, IL-6, and IL-8 separately resulted in a significant increase in CEMIP, whereas treatment with a mixture of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) in human dermal fibroblasts decreased the CEMIP messenger RNA (mRNA) levels and protein expression (17).