FLT4 and Autoimmunity: Of note is a recent publication by Li et al., in which experiments using VEGFR3-blocking antibody, LEC-specific Vegfr3 deletion mouse model, and VEGF-C/D trap, to inhibit dural meningeal lymphatic function have downplayed the contribution of dural lymphatics to pathogenic antigen drainage from the CNS to cervical lymph nodes during autoimmunity (108).