In addition to tumor-promoting immune cells (i.e. myeloid-derived suppressor cells and mast cells), the infiltrating immune cells included anti-tumor immune cells (CD8 (+) T cells and natural killer (NK) cells) and immune cells with both pro-tumor and anti-tumor effects (CD4 (+) T cells and dendritic cells) (Figure 3D). The gene discussed is CD8A; the disease is neoplasm.