ALT showed positive causal relationships with the risk of OA and gout (knee OA, OR: 2.48, 95% CI: 1.39 to 4.41; p = 2.06 × 10−3; hip OA, OR: 3.07, 95% CI: 1.49–6.30; p = 2.27 × 10−3; gout, OR: 4.94, 95% CI: 1.98–12.37; p = 6.36 × 10−4). Here, GPT is linked to gout.