In co-infected patients:↑ TNF-α, MIP-1β, and IL-9 compared with COVID-19-only.↑ TNF-α, IL-1β, IL-17A, IL-5, FGF-basic, and GM-CSFcompared with TB-only.↓ specific response to SARS-CoV-2 and Mtb. This evidence concerns the gene IL1B and COVID-19.