IFNA1 and COVID-19: Based on the evidence, individuals with highly compromised IFN-I response, which means no IFN-β and low IFN-α production and activity due to neutralizing auto-antibodies or inherited errors of type I IFN immunity, do not control the primary SARS-CoV-2 infection and they are more at risk of fatal COVID-19 (70, 146–148).