IFNG and COVID-19: In this regard, IFN-I which is strongly induced by viral infection may be detrimental in the context of Mtb by inhibiting B cell responses, inducing the release of immunosuppressive molecules or reducing the macrophagic activation induced by IFN-γ (145), Also, the hyperinflammatory milieu caused by Mtb may raise the risk of severe COVID-19 and vice versa (331).