Despite the fact that we found no significant difference in NFE2L1 and NFRKB in CDC42hiSTM and after IFN-γ stimulation, these TFs presented a plausible checkpoint that controlled the immunoproteasome enrichment in CDC42hiCD14+ cells and promoted it under the conditions of chronic IFN-γ stimulation in RA synovial tissue. Here, IFNG is linked to rheumatoid arthritis.