MTOR and asthma: To elucidate whether Sestrin2 played its role via the activation of the AMPK/mTOR signaling pathway in ASMCs from the asthma group, we overexpressed Sestrin2, followed by administration of an AMPK/mTOR inhibitor, or inhibited Sestrin2, followed by administration of an AMPK/mTOR activator in ASMCs from the asthma group.