FOSL2 and renal fibrosis: FOSL2 was expressed at low levels in the sham group, but was highly expressed in UUO-injured kidneys (Figure 2C). The upregulation of FOSL2 in the UUO model was confirmed by quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting (Figure 2D). These findings indicate that FOSL2 was strongly expressed in the mouse UUO model of renal fibrosis.