BRCA1 and neoplasm: BRCA1 mutations play an important role in facilitating genomic instability by impairing the repair of double-stranded DNA breaks through homologous recombination, resulting in a diverse genomic profile and may also facilitate robust adaptive immune response (Nagy et al., 2021), echoing its association in areas rich in regulatory T cells, the drivers of immunosuppression and tumor progression (Van Dalen et al., 2019; Li et al., 2021).