In the absence of any cure for AD, the main medications used as symptomatic therapies include cholinesterase inhibitors and excitatory amino acid receptor antagonists with limited efficacy on the cognitive-mnestic symptoms of AD (Ballard et al., 2005; Sink et al., 2005; Campbell et al., 2008; Massoud and Léger, 2011; Sato et al., 2011). Here, BCHE is linked to Alzheimer disease.