TARDBP and Alzheimer disease: As compared to younger-age AD, older-age AD patients were more likely to have common co-pathologies, including limbic-predominant, age-associated transactive response DNA-binding protein of 43 kDa (TDP-43) encephalopathy (8% vs. 35%), hippocampal sclerosis (3% vs. 15%), argyrophilic grain disease (41% vs. 58%), and vascular brain injury (39% vs. 65%) (Spina et al., 2021).