According to the key factors enriched by the p53 pathway, combined with the clinical information of the key factors in TCGA GC patients, we obtained two GC subtypes (clusters 1 and 2) to calculate the correlation between the classification and the clinical information and the results showed that there was a significant correlation between grade and subtype of GC, clarifying that the grade of GC had a greater impact on the subtype (Figure 6(a)). The gene discussed is TP53; the disease is gastric cancer.