IGF1 and Behcet disease: Squassina et al. (2013) found that the IGF1 gene was significantly overexpressed in BD patients taking lithium but only in those responding to therapy. Another study by Milanesi et al. (2015) showed that exogenous IGF-1 added to LCL culture in vitro increased lithium sensitivity in cells from non-responding BD patients – the growth of cells was inhibited in the presence of IGF-1 and 10 mM of Li.