It also enhances cholinergic activity, which effects in reducing depression-like behavior in mice (van Enkhuizen et al., 2015), as well as GABAergic activity (Jope, 1999) and serotonergic activity by inhibiting the autoreceptors 5-HT1a (serotonin 1A receptor) and 5-HT1b (Massot et al., 1999). This evidence concerns the gene HTR1A and major depressive disorder.