Furthermore, recent reports describing the potential for YRNA plasma levels to serve as powerful new biomarkers for inflammatory diseases (Driedonks et al. 2020), and perhaps most of note, for plasma levels of a YRNA fragment (originally misannotated as human miR-1975) to serve as an prognostic indicator for influenza infection clinical severity, well agree with our finding that circulating HY4 levels represent a potentially powerful prognostic indicator for SARS-CoV-2 infection outcome in patients(Liu et al. 2020). This evidence concerns the gene RNY4 and influenza.