Notably, HY4 (Figure 1C) exhibited significant differential expression when sequencing data from patients who recovered from mild SARS-CoV-2 infection (12,068 average RPM) were compared to those who suffered from severe disease (1,303 RPM) (p = 0.019), those who died from SARS-CoV-2 infection (2,496 RPM) (p = 0.032), and the combined average RPM of those who suffered from severe infection / suffered fatalities (1,932 RPM) (p = 0.025) (Figure 1D,E). Here, RNY4 is linked to infection.