To explore the effect of Hp-infection typing on the symbiosis of gastric mucosal microbiota, this study recruited 193 gastritis patients with positive rapid urease test (RUT), four serum antibodies (anti-UreA, anti-UreB, anti-CagA, anti-VacA) were detected to type Hp-infection using immunoblotting dipstick test, gastric microbiota was profiled using 16S rRNA gene high-throughout sequencing. Here, S100A8 is linked to gastritis.