SARS2 and COVID-19: For example, HIS-SARS2 interferes with immune response gene transcripts encoding inflammatory mediators – which was confirmed on fibroblast, kidney and umbilical endothelial cell lines [50,51] – and can influence the COVID-19 outcome through the nuclear activating miRNAs that interact with enhancers of genes such as the gene encoding for hyaluronan, whose accumulation was associated with progression and severe COVID-19 outcome [49].