TP53 and microcephaly: In support of this possibility, the chromatin regulator bromodomain-containing protein 8 (BRD8) was recently shown to attenuate p53 in glioblastoma (Sun et al., 2023), and we observed, in glioblastoma cells with high BRD8 levels (Wu et al., 2020), an overall increased expression for the 77 p53-DREAM targets associated with microcephaly or cerebellar hypoplasia (Fig. 4A; Table S37).