TP53 and microcephaly: Consistent with this possibility, ZIKV is known to cause p53 activation in cortical neural progenitors and microcephaly (Tang et al., 2016; Zhang et al., 2016), and genetic analyses in ZIKV-infected mice indicated that variations in clinical severity and brain pathology between different mouse strains were driven by multiple host genes with small effects (Manet et al., 2020).