We then used the univariate chi-square test to examine the relationships between HSP60 and survivin expression and a variety of clinicopathological parameters of OSCC patients, including gender, age, clinical stages, lymph node metastasis (LNM) status, pathological differentiation, and living habits like tobacco use, alcohol consumption, and areca nut chewing. Here, BIRC5 is linked to metastatic malignant neoplasm in the lymph nodes.