Finally, our findings demonstrate for the first time that pre-treatment of LD NX before Con A administration significantly attenuated all hepatic damage markers and improved liver function indicating that LD NX has the ability to protect rats from Con A-induced hepatitis via modulation of TLR4/NF‐κB and Nrf2/HO‐1 pathways. This evidence concerns the gene HMOX1 and hepatitis A virus infection.