The present study demonstrates for the first time the hepatoprotective effect of LD NX against Con A-induced autoimmune hepatitis which may be related to its ability to suppress inflammatory cytokines secretion and interfere with ROS generation via modulation of TLR4/NF-κB, Nrf2/HO-1 and JNK signaling pathways. Here, MAPK8 is linked to autoimmune hepatitis.