KEAP1 and neoplasm: We next assessed these cell lines in a xenografted murine model to explore the effect of KEAP1 SUMOylation for tumor growth in vivo. Compared with that in H1299-shKEAP1-WT tumor-bearing mice the growth of the H1299-shKEAP1-K39R tumors was greatly retarded (Fig. 6B).