Indeed, inspection of recent proteomics, transcriptomics and single-cell RNA-seq datasets reveals not only tissue-specific and cell type-specific differential mRNA and protein expression for polymerase subunits POLR1A and POLR1E for instance [W2-W5] but, significantly, that both subunits are also either up- or down-regulated upon different experimental treatments including activation of G-protein-coupled receptors, enzyme-linked receptors, nuclear receptors, protein kinases, transcription factors, or viral infections, [W6-W7]. Here, POLR1E is linked to viral infectious disease.