Despite this, significant expression in crypts of the colon and a clear association between a single nucleotide polymorphism that results in a T108M variation in transmembrane III of the protein and inflammatory diseases of the lower gut (11) has promoted substantial interest in the concept that agonists of GPR35 might be effective in the treatment of ulcerative colitis and related disorders (12). Here, GPR35 is linked to ulcerative colitis.