α-klotho acting as a scaffold for FGF23 binding to the FGFR1-3 receptors has actions independent from FGF23 that include cleavage of NaPi-IIa transporters, regulation of transient receptor potential cation channel subfamily V member 5 (TRPV5) calcium channels and modulation of renal disease [30, 65]. The gene discussed is FGF23; the disease is kidney disorder.