SLC34A1 and chronic kidney disease: This is evident in CKD as well as in primary genetic causes of hypophosphataemia such as in renal loss of phosphate due to mutations in either SLC34A1 or SLC34A3, where hypophosphataemia triggers an increase in calcitriol, leading to excessive intestinal phosphate and calcium absorption with hypercalcaemia and hypercalcuria [70].