Analysis of fluorescence-activated cell sorting (FACS)-sorted cells confirmed higher Mettl1 expression in Sca1low/CD49flow/CD24high luminal cells within prostate tumours (Fig. 5C, Supplementary Fig. S5A), which have been identified as the preferred cell-of-origin in most lineage-tracing and organoid studies [51–55]. This evidence concerns the gene METTL1 and prostate neoplasm.