Under normal growth conditions, GFP-tagged β-amyloid (1–42) (Alzheimer’s disease), Tau (Alzheimer’s/Parkinson’s disease), α-synuclein (Parkinson’s disease), amylin (type II diabetes), immunoglobin light-chain (AL amyloidosis), and serum amyloid A (AA amyloidosis) can be found throughout transfected cells (Fig. 1A,B), possessing highly soluble and mobile properties (Fig. 1C,D). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.