However, DNM1L (S616) phosphorylation, which has been proved to regulate DNM1L function in the process of mitochondrial fission positively, was significantly decreased in BCL2L13 knockdown GBM cells (Fig. 6C), indicating that BCL2L13 promotes mitochondrial fission in GBM cells by facilitating the phosphorylation of DNM1L (S616). The gene discussed is DNM1L; the disease is glioblastoma.