AKT1 and Familial prostate cancer: Fucoidan from seaweeds showed anticancer activity by enhancing the chromatin condensation, Bax, cleaved Cas-9 and poly-ADP ribose polymerase, and suppressed Bcl-2, p-PI3K, p-P38, p-Akt, and p-ERK genes in a dose-dependent manner in vitro in DU-145 prostate cancer cells111.