Similarly, fucoidan hampers PI3K, ERK, and MAPK pathway and thereby suppressing the cancer progression and also inhibits the expression of Bcl-2, Bax, and enhanced caspase-dependent apoptosis in LM3 (Murine mammary adenocarcinoma) and BEL-7402 (hepatocellular carcinoma) cell lines112. Here, BAX is linked to cancer.