In contrast to the epithelial cells, carboplatin treatment led to increased expression of pro-survival factors (Bcl2, Mcl1, Ier3, Ier5, Hmox1) in stromal cell populations, thus preserving their viability and potentially providing a means of stabilizing and prolonging the anti-tumor response (Supplementary Fig. 5d, Supplementary Data 5–7). This evidence concerns the gene IER5 and neoplasm.