FAM3A and aneurysm: Using RNA sequencing data from AngII-infused ApoE−/− aneurysm tissue, we identified 386 differentially expressed genes (DEGs) in FAM3A overexpression tissues compared to those of Ad-sham control tissues (|log2FC| > 1 and FDR < 0.05): 192 upregulated and 194 downregulated transcripts (Fig. 2d).