Given the possible roles of FAM3A in the formation of aortic aneurysm, we overexpressed FAM3A in mice using FAM3A adenovirus, and found that the diameter of aneurysms was significantly reduced and survival rate was significantly increased in the FAM3A-overexpressing mice compared to those in the empty vector virus group (Ad-sham) (Fig. 2a, b). The gene discussed is FAM3A; the disease is aneurysm.