LUM and triple-A syndrome: As shown in Fig. 4b, αSMA+CD68+, αSMA+RUNX2+, αSMA+CD34+, and αSMA+LUM+ cells were induced under AAA condition, and reversed by FAM3A overexpression mediated by adenovirus, suggesting the roles of FAM3A in suppressing VSMC transdifferentiation toward other intermediate cell types in vivo.