MYC and triple-A syndrome: As shown in Supplementary Fig. 4c, recombinant FAM3A-c-myc colacolized with VSMCs, endothelial cells, and fibroblasts, and not so obviously with macrophages in the AAA microenvironment, suggesting that the exogenous FAM3A peptide maybe target VSMCs as well as other types of cells, leading to an overall inhibitory effects on AAA formation.