As shown in Supplementary Fig. 4a, FAM3A-flag was located in VSMCs, endothelial cells, fibroblasts, and macrophages in the AAA microenvironment, suggesting that the exogenous FAM3A may be expressed in VSMCs and other cells, and may regulate VSMC activity in autocrine and paracrine manners. Here, FAM3A is linked to triple-A syndrome.