LEP and polycystic ovary syndrome: When leptin was administered peripherally, whether the rats were maintained on an ND or HFD diet, the GIR (Fig. 4b, c), GRD (Fig. 4f) and hepatic glucose inhibition rates (Fig. 4e) of CRP KO rats were significantly higher than those of WT rats, while HGP (Fig. 4d) was lower than that of WT rats, indicated that leptin inhibited HGP more pronounced in the absence of CRP in PCOS.