AKT1 and cancer: The mtPCDI prognosis model and heatmap of the 18 mtPCDI signature genes are presented in Fig. 3A. The TSC/mTOR, RTK, PI3K/AKT, RAS/MAPK, Hormone ER, DNA Damage Response, Hormone AR, EMT, Cell Cycle, and Apoptosis pathways are widely recognized as being closely linked to cancer.