We compared the mtPCDI between different subgroups of clinical pathological variables and observed significant differences in age stratification, tumor grade, chemotherapy status, 1p/19q co-deletion, IDH1 mutation status and MGMT inducer methylation position (p < 0.05) among different subgroups, as illustrated in Additional file 2: Figure S2. This evidence concerns the gene IDH1 and neoplasm.