The enhancement of immunotherapy response rates can be achieved through the integration of various treatment strategies, encompassing combination chemotherapy, targeted therapy, alternative immunotherapy approaches, cellular therapy, radiotherapy, etc. Future advancements in the field lie within the realm of immunosuppressive combined chemotherapy/targeting/novel immunotherapies, including inhibitors targeting BRCA/PI3K/AKT/mTOR/MEK/CDK4/6, androgen receptor inhibitors, ADC drugs, tumor vaccines, oncolytic viruses, and adoptive immunotherapies such as TIL and CAR-T. This evidence concerns the gene PIK3CA and neoplasm.