PIK3CA and neoplasm: The types of microenvironment included the following: (1) immune desert type: unable to attract immune cells (related to MYC gene amplification), (2) immunosuppression type: chemotaxis present, but innate immunity is inactivated and tumor antigen levels are low, possibly contributing to immune escape (possibly linked to mutations in the phosphoinositide-3-kinase (PI3K)-AKT pathway), and (3) immunoinflammatory type: demonstrating high expression of immune checkpoint molecules.