Li et al. analyzed the signaling pathway downstream of OIP5 through the proteomic kinase spectrum and found that upregulation of OIP5 can induce AKT activation through the mammalian target of rapamycin protein complex 2 (mTORC2), and P38/phosphatase and tensin homologous signal pathways, and enhance its nuclear translocation and promote tumor progression through the phosphorylation of β- catenin and glycogen synthase kinase-3β (GSK-3β). Here, PTEN is linked to neoplasm.