Ubiquitin-like containing PHD and RING finger domains 1 (UHRF1), despite being a nonhistone deacetylase protein, was significantly reduced in endothelial colony-forming cells (ECFCs) from type 2 diabetic patients, which promoted Keap1 expression by increasing the level of H3K27Ac and subsequently induced ROS overproduction and apoptosis in diabetic ECs [107]. The gene discussed is KEAP1; the disease is type 2 diabetes mellitus.