IGFBP7 promoted smooth muscle cell (SMC) or pericyte recruitment and differentiation to inhibit tumor cell growth, promote cell senescence and stabilize the tumor vasculature [44–47], and tumor growth could be promoted by IGFBP7 knockdown in vivo also was reported in another literature, which was consistent with the result mentioned above [48]. The gene discussed is IGFBP7; the disease is neoplasm.