IL6 and hypertensive disorder: Moreover, we assessed the causal effects while adjusting for potential confounding factors such as hypertension, T2DM, smoking, C-reaction protein (CRP), interleukin-6 (IL6), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride, and apolipoproteins through multivariable MR analysis (MVMR).